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Toxicity to microorganisms

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Description of key information

The 30-min and the 3-hour EC50 of ITC 288/S were found to be greater than 1000 mg/L.

The 30-min and the 3-hour NOEC of ITC 288/S were found to be greater or equal than 1000 mg/L.

Key value for chemical safety assessment

Additional information

One study on the assessment of the inhibitory effect of the test material ITC 288/S on the respiration of activated sewage sludge is available. The method followed that described in the OECD Guidelines for Testing of Chemicals (1984) No. 209 and the test was performed according to the GLP. Therefore, this study is considered as reliable without restriction.

The respiration rate of an activated sludge of a predominantly domestic sewage was measured after contact times of 30 minutes and 3 hours with the test material of a concentration of 1000 mg/L. The inhibitory effect of the test material was determined by comparison with the respiration rate of two controls.

After 30 minutes of contact no inhibition was observed and after 3 hours of contact 12 -14% of inhibition was observed. Therefore, the 30 -min and 3-hr EC50 for the test material to activated sludge were greater than 1000 mg /L.

The NOEC values are not reported in the test report. As the inhibition of the respiration rates observed was below than the accepted variation of the respiration rates of the controls in the guideline, it can be concluded that no significant inhibition of the respiration rate was observed at the tested concentration. Therefore, the 30 -min and 3-hour NOEC of ITC 288/S were found to be greater or equal than 1000 mg/L.

The validity criteria of the OECD TG were fulfilled.