Registration Dossier
Registration Dossier
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EC number: 410-800-5 | CAS number: 143239-08-1 ITC 288/S
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
One study was available for this endpoint and was considered as the key study (Kr: 1). In a dermal sensitization study (Tuffnell PP, 1992), female albino Dunkin-Hartley guinea pigs (20 tested + 10 control) were used to test the skin contact sensitisation potential of ITC 288/S using the method of guinea pigs maximisation test (OECD 406, method B6 in Commission Directive 84/449/EEC) and in compliance with GLP. In this study, ITC 288/S induced evidence of skin sensitisation in 58 % of the animals at challenge readings (score 1 at 24h and 48 h) following topical application at 50%. Based on this result, ITC 288/S should be considered as a sensitizer by skin contact.
Migrated from Short description of key information:
Positive in guinea pigs maximisation test (OECD 406, Kr: 1), and therefore classified as skin sensitizer.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
Migrated from Short description of key information:
No data was available
Justification for classification or non-classification
Skin sensitisation:
ITC 288/S produced a 63 % (12/19) sensitisation rate (OECD 406, Kr:1). Therefore ITC 288/S was classified in category 1B, H317 ( May cause an allergic skin reaction) according to the CLP regulation (1272/2008) and as a sensitiser to guinea pig skin (Xi, R43) according to the Directive 67/548/EEC.
Respiratory sensitisation:
Classification not possible due to lack of data.
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