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EC number: 231-225-4
CAS number: 7452-79-1
Intradermal treatment with 25% ethyl 2-methylpentanoate caused severe
erythema and abscesses. Slight to moderate erythema and abscesses were
induced by the 5 and 12.5% concentrations. Topical application of 5,
12.5 or 25% ethyl 2-methylpentanoate in vaseline induced no erythema. Based
on these results a 25% concentration was used for intradennal injections
as well as for challenge treatment in the main test.
Four males (two controls and two test animals) and three females (two
controls and one test animal) died in the course of the study, because
of a rectal prolapse. All other
animals remained in good health during the experimental period.
The scores of the skin reactions made during the induction phase of the
study are given in appendix 2 of attached report. The
intradermal injections caused the following reactions:
Freund’s Complete Adjuvant (FCA): moderate to severe erythema and slight
oedeuia in all test and control animals
- with the
25% dilution of the test substance in PG: moderate to severe erythema
and abscesses in all test animals
- with PG
alone: slight to moderate erythema and abscesses in all controls
- with the
25% dilution of the test substance in a mixture of FCA and PG (1:1):
moderate to severe erythenia and abscesses in all test animals and
slight oedema in nearly all test animals
- with the
mixture of FCA and PG alone: moderate to severe erythema and abscesses
in all control animals and slight oedema in nearly all animals.
applications of the 25% dilution of the test substance in vaseline, made
in the induction phase, did not induce erythema in any of the test
animals. Vaseline alone did not induce skin reactions in any of the
The results of the challenge treatment are given in table 1 of attached
challenge treatment with the 25% dilution of the test substance in
vaseline did not induce skin reactions in any of the test animals or the
controls, either after 24 h or after 48 h.
1. The test
substance ethyl 2 - methylpentanoate was examined for possible
sensitizing properties by a maximization test in guinea pigs using 20
control and 20 test animals.
2. The test
treatment by intradermal injection of 25% test substance in propylene
glycol, followed one week later by a topical treatment with 25% in
treatment, 14 days after the last induction, by topical application of
25% in vaseline,
The challenge treatment with the 25% dilution did not induce signs of
sensitization in any of the guinea pigs under the conditions of the
test. Therefore, it was concluded that the test substance is a non -
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