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Link to relevant study record(s)

basic toxicokinetics in vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:

Description of key information

EMB is rapidly absorbed from the GI tract, metabolised to endogenous compounds, ultimately being eliminated as carbon dioxide.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information


Short branched chain carboxylic acids and their esters are rapidly absorbed from the gastrointestinal tract.


Hydrolysis of ethyl 2-methyl butanoate catalysed by esterases occurs in the gastrointestinal tract, skin, blood or liver forming ethanol and 2-methyl butanoic acid. 

The free carboxylic acid undergoes β-oxidation; this reaction involves initial esterification with the thiol group of coenzyme A (CoA) followed by

oxidation and finally cleavage forming acetyl-CoA and propionyl-CoA. The oxidation products are all endogenous compounds and enter the tricarboxylic acid cycle (TCA), ultimately being eliminated as carbon dioxide.


Safety evaluation of certain food additives and contaminants. WHO Food Additives Series, No. 40, 1998.

Evaluation of certain food additives and contaminants. WHO Technical Report Series, No. 884, 1999.