Registration Dossier
Registration Dossier
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EC number: 243-296-9 | CAS number: 19780-11-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
2-Dodecenyl-1-yl succinic anhydride was tested in three standard sensitisation protocols, the guinea pig maximization test, the adjuvant and patch test and Buehler test. The substance was positive in all three tests. The chemical reactivity of nDDSA with 2-phenylethylamine was also tested and found to be highly reactive. The log P was estimated to be 5.0. These data, taken altogether, suggest that nDDSA penetrates the skin easily and reacts readily with proteins containing amine groups. This may explain the sensitisation results observed.
Migrated from Short description of key information:
2-Dodecenyl-1-yl succinic anhydride was tested in three standard sensitisation protocols, the guinea pig maximization test, adjuvant and patch test and Buehler test. The substance was positive in all three tests.
Justification for selection of skin sensitisation endpoint:
scientifically valid study employing three standard sensitisation protocols
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
2-Dodecenyl-1-yl succinic anhydride (nDDSA) was positive (sensitising) in three standard sensitisation protocols in guinea pigs, the guinea pig maximization test, adjuvant and patch test and Buehler test. This meets the criteria for classification as a dermal sensitiser according to Regulation EC No. 1272, 2008.
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