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EC number: 243-296-9
CAS number: 19780-11-1
Testing for bioaccumulation in aquatic species was waived. The substance has a low potential for bioaccumulation, and direct or indirect exposure of the aquatic compartment is unlikely. Therefore, bioaccumulation testing of the substance in aquatic species is not indicated, in accordance with Regulation (EC) No.1907/2006, Annex IX, Column 2.
According to Regulation (EC) No.1907/2006, Annex IX, Column 2,
bioaccumulation testing in aquatic species, preferably fish, need not be
conducted if the substance has a low potential for bioaccumulation (for
instance a log Kow< 3), or if direct or indirect exposure of
the aquatic compartment is unlikely. Although the
experimentally-determined octanol-water partitioning coefficient for the
substance (log Kow= 4.38) exceeds the criterion log Kowof
3, the substance nevertheless exhibits a low potential for
bioaccumulation. The substance has been shown to undergo rapid
hydrolysis at environmentally relevant pH and temperature conditions (i.e.,
at pH 7, DT50= 76 minutes at 15oC and DT50=
35 minutes at 25oC). Each of these hydrolysis half-life
values is substantially below the threshold half-life of 12 hours, below
which “it can be assumed that the rate of hydrolysis is greater than
that for uptake by exposed organisms” (Chapter R.7.c, “Endpoint-specific
guidance”, Guidance on information requirements and chemical
safety assessment, ECHA, May 2008, Section R.188.8.131.52, p. 24). The
ECHA guidance subsequently states that “in most cases hydrolysis
products are more hydrophilic and as a consequence will have a lower
potential for bioaccumulation” (Ibid.). The
experimentally-determined partition coefficient for the substance (log Kow=
4.38), falls below the screening criterion for “not bioaccumulative” and
“not very bioaccumulative” (i.e., log Kow≤
4.5) in the PBT/vPvB evaluation (Chapter R.11, “PBT Assessment”,Guidance
on information requirements and chemical safety assessment, version
1.1, ECHA, November 2012, Section R.184.108.40.206, p. 30); the hydrolysis
product is expected to be more hydrophilic and also not of concern with
respect to bioaccumulation. Therefore, bioaccumulation testing of the
substance in aquatic species is not indicated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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