3-(2-dodecenyl)succinic anhydride

Hydrolysis

Description of key information

 Aqueous abiotic hydrolysis would be expected to contribute significantly to the degradation of n-DDSA at pH 7.0 under the conditions associated with typical use and/or exposure in the environment.  At pH 7.0, half-lives were determined to be 76 min. at 15 ºC , 35 min. at 25 ºC and 14 minutes at 35 ºC.

Key value for chemical safety assessment

Half-life for hydrolysis:

35 min

at the temperature of:

25 °C

Additional information

In the study entitled “n-DDSA Determination of the Abiotic Degradation of the Test Substance by Hydrolysis at Three Different pH Values Following OECD Guideline 111, The Official Journal of the European Communities L 142/518 Method C.7 and OPPTS Guideline 835.2120 and the Estimation of Water Solubility” a preliminary Tier 1 study was not conducted since n-DDSA is known to be hydrolytically unstable at pH 7.0. A Tier 2 test was conducted following OECD Guideline 111. At pH 7.0, half-lives were determined to be 76, 35 and 14 minutes at 15 ºC, 25 ºC and 35 ºC, respectively. The calculated half-life based on the Arrhenius Equation at 25 ºC was 33 minutes at pH 7.0. Based on these results, aqueous abiotic hydrolysis would be expected to contribute significantly to the degradation of the test substance at pH 7.0 under the conditions associated with typical use and/or exposure.