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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The substance was experimentally determined to be irritating to the skin.  It is acknowledged by "read-across" within a chemical category to be an eye irritant.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

2 -Dodecenyl succinic anhydride was applied to the clipped skin of rabbits for 4 hours in a OECD 404 guideline study, resulting in a primary dermal irritation index score of 6.4 (of 8) after 72 hours. This corresponds to classification as a severe skin irritant.

No specific testing was performed for eye irritation. It is acknowledged to be an eye irritant, "reading-across" from the findings of other members of the C8-12 Alkenyl Succinic Anhydride category. This specifically applies to tetrapropenyl succinic anhydride, where conjunctival irritation did not fully resolve by day 14 after administration. Tripropenyl succinic anhydride is also an eye irritant.

A category approach is used for the hazard assessment of several endpoints. The hypothesis for the category of C8-12 Alkenyl Succinic Anhydrides is that data can be read-across among members of the category because their properties and behaviours are similar, based on common functional groups and similar breakdown products, and based on a constant pattern in changing of the potency of properties of the various carbon chain lengths. Functional groups include a dihydro-2,5 -furandione cyclic anhydride ring, a carbon chain of length 8 -12 carbons, and a single double-bond within the carbon chain. The primary functional group associated with toxicity is the succinic anhydride moiety, which quickly is hydrolysed to form a butanedioic acid. A constant pattern may also be displayed in acute toxicity, dermal irritancy and biodegradation, with the lowest carbon chain length (C8) displaying the highest activity. Irritation, toxicity and degradation potential diminish with increasing carbon chain length. Read-across among the category members is substantiated by the common behaviour in physico-chemical and toxicity behaviours, as provided in the Chemical Category Report Format (CCRF) attached to the IUCLID file. It is adequate to fulfill the information requirements of Annex IX, to be the basis for classification and labelling decisions, and for risk assessment. 

Justification for selection of skin irritation / corrosion endpoint:
guideline study under GLP

Justification for selection of eye irritation endpoint:
guideline study on a category member

Effects on skin irritation/corrosion: highly irritating

Effects on eye irritation: irritating

Justification for classification or non-classification

2 -Dodecenyl succinic anhydride is classified as a severe skin irritant, Category 2, according to Regulation EC No. 1272/2008. The substance is classified as an eye irritant, Category 2, by "reading-across" from tetrapropenyl succinic anhydride, a member of the C8 -12 Alkenyl Succinic Anhydride category.