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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report Date:
2004

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: OECD 429, OPPTS 870.2600
GLP compliance:
yes
Type of study:
mouse local lymph node assay (LLNA)

Test material

Reference
Name:
Unnamed
Type:
Constituent

In vivo test system

Test animals

Species:
mouse
Strain:
CBA
Sex:
female

Study design: in vivo (non-LLNA)

No. of animals per dose:
Number of animals in test group: 4
Number of animals in negative control group: 4

Study design: in vivo (LLNA)

Vehicle:
dimethylformamide

Results and discussion

Any other information on results incl. tables

Comments:
Test substance - results and comments


Concentration of test   DPM/lymph node   Test:control ratio

substance (% w/v)


0 (vehicle control)     425              N/A

0.25                    810              1.91

0.5                    1879              4.42

1                      2625              6.18


Summary of results: C3RO is a skin sensitiser under the
conditions of the test

-----------------------------------------------------------


Positive control substance (hexylcinnamaldehyde) - results
and comments


Concentration of test   DPM/lymph node   Test:control ratio

substance (% w/v)


0 (vehicle control)*    665              N/A

2.5                     921              1.38

5                       938              1.41

10                     2085              3.14


*4:1 acetone in olive oil


Summary of results: A sensitiser under the conditions of the
test.

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information