Benzeneacetic acid, .alpha.-hydroxy-, (.alpha.R)-(1R,2S)-compd. with 2-(3,4-difluorophenyl)cyclopropanamine (1:1)

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2004

Report date:

2004

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

454-140-6

EC Name:

-

Cas Number:

376608-71-8

Molecular formula:

C9H9F2N*C8H8O3

IUPAC Name:

(1R)-2-(3,4-difluorophenyl)cyclopropan-1-aminium (2R)-2-hydroxy-2-phenylacetate

Constituent 2

Reference substance name:

trans-(1R,2S)-2-(3,4-difluorophenyl-cyclopropanaminium (2R)- 2-hydroxy-2-phenylethanoate

IUPAC Name:

trans-(1R,2S)-2-(3,4-difluorophenyl-cyclopropanaminium (2R)- 2-hydroxy-2-phenylethanoate

Results and discussion

Water solubility

Water solubility:

> 6 850 - < 7 150 mg/L

Temp.:

25 °C

pH:

> 5.71 - < 5.78

Details on results:

Result by UV Analysis : 7000 ± 150mg/l at 25°C ± 1°C. Test 1 : 6995mg/l at 25°C ± 1°C. Test 2 : 6983mg/l at 25°C ± 1°C. Test 3 : 6958mg/l at 25°C ± 1°C. Test 4 : 6880mg/l at 25°C ± 1°C. Test 5 : 7095mg/l at 25°C ± 1°C.