Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
other information
Study period:
No data
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature (evaluation and comparison of available data on alipathic amines)
Reason / purpose for cross-reference:
reference to same study

Data source

Reference Type:
Toxicity of aliphatic amines: structure-activity relationship
Greim H, Bury D, Klimisch H J, Oeben-Negele M, Ziegler-Skylakakis K
Bibliographic source:
Chemosphere, Volume 36, Issue 2, Pages 271–295

Materials and methods

Test material

Constituent 1
Reference substance name:
aliphatic amines
aliphatic amines
Details on test material:
Various aliphatic amines (17 primary, 11 secondary and 9 tertiary amines).

Results and discussion

Applicant's summary and conclusion

After intravenous application of primary aliphatic amines, they were detected in the lung, liver, kidney, heart, spleen and brain. Metabolism found included oxidization via monoamine oxidase to aldehydes, followed by metabolic conversion to carboxylic acids via dehydration. Furthermore beta-oxidation was observed resulting in excretion of CO2. Monoamine oxidase selective binding was reduced with increasing chain length of the amines. Moreover the excretion via CO2 was found to be dependent on the chain lenght, too. Primary amines with C6 were shown to have the highest elimination rate via CO2. The rate diminishes with alterations in chain length (increasing as well as decreasing; <>>). Some amines are excreted mostly unmetabolised in the urine (e.g. ethylamine or diethylamin).