Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 239-556-6 | CAS number: 15520-10-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The lowest reliable 48 h EC50 for daphnids was 19.8 mg/L. However, a further reliable 48 h EC50 of 50 mg/L is reported and a supporting study reports an EC50 (48 h) between these both extreme values of 27 mg/L. For this reason a geometric mean of the two Key studies is used to generate an EC50.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 31.5 mg/L
Additional information
Two reliable acute toxicity studies for the category member HMD with Daphnia magna are available. pH-values of both studies were in the range recommended by OECD 202. Both are considered as reliability category 2 despite the lack of chemical analysis as the substance would be relatively stable in an aqueous solution within a period of 48 hours.
The 48h-EC50 of 19.8 mg/L reported for HMD in the study performed by Stahl & Wetzel (1985, No. 303-85) is lower than the EC50(48 h, Daphnia magna) of 50 mg/L determined for the same substance by Ziegenfuss & Adams (1984, No. ESC-EAG-84-8). There are no obvious reasons to prefer either of these studies. On the other hand, an EC50(48 h) of 27 mg/L from a supporting study is available (performed by MITI Japan, 2002, not assignable due to missing documentation). This latter result corroborates the recommendation of REACH guidance on Information Requirements and Chemical Safety Assessment, part R.10 to take the geometric mean from both EC50-values of the two reliable studies. The EC50 aquatic invertebrates for the amine heads category is therefore based on the geometric mean of the two valid studies, resulting in 31.5 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Route: .live1