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EC number: 239-556-6 | CAS number: 15520-10-2
Experiment I (Vehicle acetone): EC3 = 0.4 (EC1.5 = 0.6)
Experiment II (vehicle acetone): EC1.5 = 0.89
Experiment III (Vehicle acetone/olive oil): no EC value determined as SI of 1.5 was never exceeded
Groups of 6 female CBA mice per dose group were used to test skin sensitisation properties of the test material in three independent experiments. Experiment I was conducted using acetone as vehicle with concentration levels of 0.1%, 0.3% or 1%. Experiment II was performed using acetone as vehicle but concentration levels of 0.3%, 1% and 3%. Experiment III was performed using the same concentration levels but instead aceton/olive oil as vehicle. Experiment I resulted in an EC3 value of 0.4%. Experiment II resulted in an EC1.5 value of 0.89%. An EC3 value could not be determined as a Stimulation index of 3 was never achieved even though higher test material concentrations were used. In Experiment III even an EC1.5 value could not be calculated as the Stimulation index of 1.5 was never exceeded. It has to be mentioned that Experiment III should have been conducted using higher test material concentration based on expected results of the pre-testing or irritant properties in the respective test vehicle. Hence a somewhat different result could be expected for Experiment III (maybe even an EC3 value).
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