Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From September 29, 2010 to September 30, 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study conducted in compliance with international guidelines.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2011
Report Date:
2011

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
other: individual solibilities in n-octanol and in water by shake-flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
< -3.1
Remarks on result:
other: The partition coefficient, log POW, of test item was calculated from the individual solubilities in n-octanol and in water respectively to be 474.5 µg/mL and >584099.2 µg/mL

Applicant's summary and conclusion

Executive summary:

The determination of the partition coefficient log POW of the test item was performed using the flask shaking method as described in OECD guideline no. 117, “Preliminary estimate of the partition coefficient”. The solubility in water was determined in the preliminary test of Harlan Laboratories study C77461 and the solubility in n-octanol was determined using a simplified flask method. The solubility in water was found to be clearly above the solubility in n-octanol indicating a partition coefficient below -2. Hence, a main test according to OECD Guidelines 107/117 (either HPLC or flask shaking method) could not be applied. Based on the individual solubilities in n-octanol and in water, respectively, the log POW was calculated to be: log POW =< -3.1 at 22°C. The pH in the aqueous phase (determined in Study C77145) was between 1.15 and 1.27.