Ethanol, 2-[(3-aminopyrazolo[1,5-a]pyridin-2-yl)oxy]-, hydrochloride (1:1)

Surface tension

Administrative data

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From October 04, 2010 to October 06, 2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP study conducted in compliance with international guidelines.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2011

Report date:

2011

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

ring method

Test material

Test material information

Constituent 1

Reference substance name:

2-({3-aminopyrazolo[1,5-a]pyridin-2-yl}oxy)ethan-1-ol hydrochloride

EC Number:

695-745-7

Cas Number:

1079221-49-0

Molecular formula:

C9 H11 N3 O2, ClH

IUPAC Name:

2-({3-aminopyrazolo[1,5-a]pyridin-2-yl}oxy)ethan-1-ol hydrochloride

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Results and discussion

Surface tension

Surface tension:

72.7 mN/m

Temp.:

19.5 °C

Conc.:

1 g/L

Any other information on results incl. tables

In order to calculate the surface tension, the values read on the apparatus were multiplied by the calibration factor Φb. This yields a value, which is only approximate and requires additional correction. The additional correction was made using the factor for correction Fc compiled on the basis of Harkins-Jordan correction (W. D. Harkins, H. F. Jordan, J. Amer. Chem. Soc. 52, 1751, 1930).

The calibration factor Φb was determined to be 1.0195 for double distilled water.

Applicant's summary and conclusion

Conclusions:

According to the criteria as mentioned in the directive, substances showing a surface tension lower than 60 mN/m under the conditions of this method, should be regarded as being surface active material. Thus the test item has to be considered as a not surface active substance.

Executive summary:

The determination of the surface tension of an aqueous solution of the test item was based on the OECD Guideline No. 115: “Surface Tension of Aqueous Solutions” (1995) and on the EEC Directive 92/69, EEC Publication No. L383, December 1992 and the Council Regulation (EC) No. 440/2008, 30 May 2008, Part A, Methods for the determination of physico-chemical properties, A.5 “Surface tension”.

The surface tension of the test item in water (at a concentration of about 1 g/L) was determined to be 72.7 mN/m at 19.5 °C ± 0.1 °C. Based on the criteria as outlined in the EEC Guideline and the results of this study, the test item has to be considered as a not surface active substance.