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EC number: 695-745-7
CAS number: 1079221-49-0
summary: % viability and IL-1αconcentrations
This product presents results with a high
variability due to the physical form of the raw material.
vitro evaluation of skin
irritation was performed on the reconstructed human epidermis model
Episkin small model (0.38cm²), with a method equivalent to OECD
guideline 439 (GLP study, scored as validity 2 according to Klimisch
criteria). The colored raw material was tested according to the specific
coloring protocol. The test substance was qualified on 4 batches of
reconstructed epidermis model and it was also tested on dead epidermis
because of its interaction with MTT.
tests item was tested undiluted. Negative and positive controls were
tested in triplicate. The duration of treatement was 15 minutes,
followed by an incubation period of 42h at 37°C. MTT test and
determination of IL-1αconcentration
mean of percentage of viability was 67.4% ± 17.6 and the mean of IL-1αconcentration
21.5 ± 14.4.
on the experimental conditions used, the in vitro evaluation of
acute skin irritation by using the reconstructed human epidermis
Episkin(SM) model, suggests that the test item tested undiluted is
considered as potentially non irritant.
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