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Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to guideline
Guideline:
other: OECD Guideline 105 and ETAD Guideline
Principles of method if other than guideline:
The partition coefficient was estimated based on the ratio of the solubilities in n-octanol and in water.
The individual solubilities were determined by the flask method based on OECD Guideline 105 and the ETAD method.
GLP compliance:
no
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
0
Temp.:
20 °C
Remarks on result:
other: no data on pH
Details on results:
Detailed results:
3 independent vials from each solubility test were injected and measured. Each result given in the table below is the average of these 3 measurements.
The solubility in n-octanol and in water is 25 µg/L.

Estimation of log Pow:

Pow= c(n-octanol) / c( water)= 25 µg/L / 25 µg/L= 1

Log Pow= 0

Conclusions:
The partition coefficient of test substance was estimated to be log Pow= 0 at 23°C.

Description of key information

Estimated based on solubility ratio:

log Pow= 0 at 23°C

Key value for chemical safety assessment

Log Kow (Log Pow):
0
at the temperature of:
23 °C

Additional information

The partition coefficient was estimated based on the ratio of the solubilities in n-octanol and in water.

The individual solubilities were determined by the flask method based on OECD Guideline 105 and the ETAD method. The quantification was analyzed by HPLC-UV.