Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 214-711-0 | CAS number: 1189-08-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to fish
Administrative data
- Endpoint:
- fish early-life stage toxicity
- Data waiving:
- exposure considerations
- Justification for data waiving:
- other:
- Justification for type of information:
- The risk characterisation of 1,3-BDDMA shows that the PEC/PNECaqua ratio for the aquatic environment is <1, indicating no need for further information or testing. According to REACH regulation Annex IX, 9.1. column 2, long-term toxicity testing shall only be considered when the chemical safety assessment indicates the need for further investigations. Because there is no indication of major differences in sensitivity between trophic levels and in the absence of any significant long-term bioaccumulation potential it is not necessary to perform further chronic fish tests with the substance.
The environmental risk assessment can be performed with sufficient reliability with the available long-term ecotoxicity data based on the analogue substance 1,4-BDDMA. The analogue substances 1,3-BDDMA and 1,4-BDDMA are very similar in structure without steric differences. For more details please also refer to document “Overview phys-chem properties 1,3-BDDMA and 1,4-BDDMA” as attached in this endpoint. Thus, no long-term toxicity testing fish is required for 1,3-BDDMA.
In addition, the results of the Long-term toxicity to aquatic invertebrates study (Daphnia magna Reproduction test, 21d, OECD 211) and the Toxicity to aquatic algae and cyanobacteria study (Alga, growth inhibition test, 72h, OECD 201) are in progress. Once the pending results of 1,3-BDDMA are available, the exposure and risk assessment will be updated. We expect to have the results of the OECD 211 by 30th June 2021 and OECD 201 by 10th December 2020 in a draft report. Based on a tiered testing approach, next steps might be considered depending on the test results. For more details, please also refer to IUCLID Section 6.1.4 & 6.1.5. This approach seems justified also due to animal welfare reasons.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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