Registration Dossier
Registration Dossier
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EC number: 214-711-0 | CAS number: 1189-08-8
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The NOEC of the structural analogue 1,4-BDDMA in microorganisms was 20 mg/L.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 20 mg/L
Additional information
One toxicity screening study conducted during the OECD 310 biodegradation test is available for the structural analogue 1,4-BDDMA, which is considered reliable without restriction (Klimisch score 1). A Bringman-Kühn test with 1,3-BDDMA with not assignable reliability (Klimisch score 4) is used as supporting data.
The toxicity of 1,4 -BDDMA to microorganisms was investigated during a ready biodegradation study according to OECD guideline 310 (Headspace Test), adopted 23 March 2006, over a period of 28 days and using predominantly domestic non-adapted activated sludge as inoculum.
The biodegradation rate was determined by measurement of carbon dioxide evolution.
Inoculum blank, procedural/functional control with the reference substance Sodium benzoate and toxicity control with reference substance and test substance (20 mg/L test substance) were performed.
The 10% level (beginning of biodegradation) was reached after 2 d. The pass level of 60% was reached after 9 d and the biodegradation came to 84% after 28 d. The biodegradation of the toxicity control reached 83% within 14 d and it came to 89% after 28 d. The biodegradation of the reference item was not inhibited by the test item in the toxicity control. The 95% confidence interval on day 28 was 86 - 93%
Therefore, the test substance was assumed not to inhibit microbial activity at a concentration of 20 mg/L.
In a 16-h toxicity study conducted according to the Bringmann-Kühn test, cultures of Pseudomonas putida were exposed to 1,3 -BDDMA at a nominal concentration of 50 mL/L (corresponding to 512 mg/L based on a denstity of 1.024 g/cm³). The EC10 was > 512 mg/L. No higher concentrations were tested. However, the sample was insoluble in water. The maximum water solubility is 243 mg/L (for experimental result see Water solubility).
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