Registration Dossier
Registration Dossier
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EC number: 214-711-0 | CAS number: 1189-08-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Methacrylic acid and derivatives
- Author:
- Nemec JW, Kirch LS
- Year:
- 1 981
- Bibliographic source:
- Kirk-Othmer, Encyclopedia of chemical technology, 3rd edition, Volume 15, p 346-376
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- 1-methyltrimethylene dimethacrylate
- EC Number:
- 214-711-0
- EC Name:
- 1-methyltrimethylene dimethacrylate
- Cas Number:
- 1189-08-8
- Molecular formula:
- C12H18O4
- IUPAC Name:
- 4-[(2-methylprop-2-enoyl)oxy]butan-2-yl 2-methylprop-2-enoate
- Details on test material:
- Purity not specified, but commercial grade assumed.
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 1,3-butylene dimethacrylate
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD50 of 1,3-BDDMA is reported to be >3000 mg/kg bw in rabbit.
Based on the low systemic toxicity after acute oral administration and the calculated low dermal absorption potential (Heylings 2013, see chapter Toxicokinetics), no classification according UN-GHS is warranted. - Executive summary:
The acute dermal LD50 of 1,3-BDDMA is reported to be >3000 mg/kg bw in rabbit.
Based on the low systemic toxicity after acute oral administration and the calculated low dermal absorption potential (Heylings 2013, see chapter Toxicokinetics), no classification according UN-GHS is warranted.
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