Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Limited details available. LD50 was cited in Kirk-Othmer which was false (aminal tested was the mouse see original Lawrence WH et al. 1972 instead of the rat which was cited in Kirk-Othmer).

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1972
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1981

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-methyltrimethylene dimethacrylate
EC Number:
214-711-0
EC Name:
1-methyltrimethylene dimethacrylate
Cas Number:
1189-08-8
Molecular formula:
C12H18O4
IUPAC Name:
butane-1,3-diyl bis(2-methylacrylate)
Details on test material:
- Name of test material (as cited in study report): 1,3-butylene dimethacrylate

Test animals

Species:
mouse
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 640 mg/kg bw
Remarks on result:
other: Original value: LD50: 16.063 mol/ 10E6 gm (95% confidence limit: 14.335 - 18.005 mol/10E6 gm) i.p., mice

Applicant's summary and conclusion

Conclusions:
The acute intraperitoneal LD50 of 1,3-BDDMA is reported to be 3640 mg/kg bw in mice.
Executive summary:

The acute intraperitoneal LD50 of 1,3-BDDMA is reported to be 3640 mg/kg bw in mice.