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EC number: 204-638-2 | CAS number: 123-62-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted under GLP in a modern laboratory
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD 111
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: EEC Annex V, Part C7
- Principles of method if other than guideline:
- The purpose of this test is to determine tbe potential of propionic anhydride to undergo hydrolysis in a saline:rat serum solution (1:3, v:v). A saline:serum mixture was used because adding the test material (in acetonitrile) directly to tbe serum resulted in a cloudy solution, suggesting serum protein denaturation by either tbe test substance, the solvent (acetonitrile), or both. Information pertaining to the hydrolytic stability of propionic anhydride is useful for hazard identification and risk assessments. If the hydrolysis reaction is fast, then hazard identification and risk assessment should focus on propionic acid, tbe product of hydrolysis. Additional animal testing on the anhydride would be unnecessary.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Propionic anhydride
- EC Number:
- 204-638-2
- EC Name:
- Propionic anhydride
- Cas Number:
- 123-62-6
- Molecular formula:
- C6H10O3
- IUPAC Name:
- propanoyl propanoate
- Details on test material:
- Name: propionic anhydride
EAN: 901291
Sample Reference Number: 05-01
CAS Number: 123-62-6
Date Received: May 10,2001
Constituent 1
Results and discussion
Any other information on results incl. tables
Determination | K obs | t 1/2 minutes |
1 | 4.4478 | 0.16 |
2 | 6.1200 | 0.11 |
3 | 5.1805 | 0.13 |
mean | --- | 0.13 |
Applicant's summary and conclusion
- Executive summary:
The potential of the test substance to undergo hydrolytic degradation in rat serum was studied in GLP conformance using a procedure similar to those outlined in: OECD Guideline No. 111, EEC's Annex V, Part C.7, EPA's Chemical Fate Guidelines and EPA's Pesticide Assessment Guidelines. The hydrolysis testing was performed at 26 ± 0.5 C in a saline:rat serum solution (1:3, v:v). This diluting solution contained twenty-five percent by volume of physiological saline prior to the introduction of the test substance. A test substance stock solution was prepared in acetonitrile. The test systems were prepared by adding 10 uL aliquots of the stock solution to 0.5 mL of the saline:rat serum solution (1:3, v:v), resulting in an approximate acetonitrile concentration of 2% in each test system. Inorder to quench hydrolysis, acetonitrile was then added at timed intervals to achieve 80% acetonitrile by volume in each test system. Test solutions were analyzed for the test substance using gas chromatography with flame ionization detection (GC/FID). The initial work done in rat serum indicated that the test substance hydrolyzed at such a fast rate that our conventional means of test system preparation and multiple sampling from a single test system would not be adequate for determining the half-life. Therefore, the study was performed by preparing eight separate test systems and quenching the hydrolysis in each test system at timed intervals during a 2-minute period. The change in test substance concentration, over time, was calculated and reported as the percent hydrolysis. The natural logarithm (In) of the test substance concentration (mg/L) versus time (minutes) was plotted and the best-fit line, as determined by a linear regression analysis, was used to calculate the observed rate constant (Kob) and the half-life (t ½). The study was performed three times. The mean (n=3) half-life of the test substance in the saline solution of rat serum was 0.13 minutes.
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