Registration Dossier
Registration Dossier
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EC number: 204-638-2 | CAS number: 123-62-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guidline study with accepted restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- According to Fed Reg 38 No.187 § 1500.41
- GLP compliance:
- no
Test material
- Reference substance name:
- Propionic acid
- EC Number:
- 201-176-3
- EC Name:
- Propionic acid
- Cas Number:
- 79-09-4
- Molecular formula:
- C3H6O2
- IUPAC Name:
- propanoic acid
- Details on test material:
- - Name of test material (as cited in study report): Propanoic add; propionic acid; CP 66423
- Analytiucal purity: no data
- D-1 Product 5/7/75
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 µl - Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
SCORING SYSTEM: no data
TOOL USED TO ASSESS SCORE: no data
Results and discussion
In vivo
Results
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1 min
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive with in 1 min. No evaluation of iris, erythema and chemiosis was done therefore
- Irritant / corrosive response data:
- Immediately after instillation: Severe discomfort with pawing, squealing, and thrashing about the stock
After 1 min: Corrosive
After 14 days: Ulceration
Applicant's summary and conclusion
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