Registration Dossier
Registration Dossier
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EC number: 204-638-2 | CAS number: 123-62-6
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- The results of skin testing with food additives and the effect of an elimination diet in chronic and recurrent uticaria and recurrent angioedema.
- Author:
- Malanin and Kalimo
- Year:
- 1 989
- Bibliographic source:
- Clin. Exper. Allergy 19: 539-543 [as cited in SIDS Document for SIAM 25-Propionic acid, 01-07-2007
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Pin prick trials
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propionic acid
- EC Number:
- 201-176-3
- EC Name:
- Propionic acid
- Cas Number:
- 79-09-4
- Molecular formula:
- C3H6O2
- IUPAC Name:
- propanoic acid
- Details on test material:
- no data
Constituent 1
Method
- Type of population:
- other: Patients suffering from chronic urticaria
- Controls:
- non-urticria individual
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- A reproducible positive pin-prick response to a 5% aqueous solution of propionic acid was obtained in 3 of 91 patients suffering from chronic uticaria; patients were presumed to have prior exposure with propionic acid as a food preservative. There was no response observed among 247 normal control (non-uticaria) subjects.
Applicant's summary and conclusion
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