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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study was conducted in a reputable laboratory to the state of the art at the time of conduct.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1953
Report date:
1994

Materials and methods

Principles of method if other than guideline:
Test method: Eastman Kodak Company, Health, Safety and Human Factors Laboratory Protocol
GLP compliance:
no
Remarks:
(prior GLP codification)
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Propionic acid
EC Number:
201-176-3
EC Name:
Propionic acid
Cas Number:
79-09-4
Molecular formula:
C3H6O2
IUPAC Name:
propanoic acid
Details on test material:
- Name of test material (as cited in study report): propionic acid

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
TEST SITE
- Area of exposure: abdomen
- % coverage: no data
- Type of wrap if used: no data


REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data

Duration of exposure:
24 h
Doses:
2.5, 5, or 10ml/kg
No. of animals per sex per dose:
1 animal/dose
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 950 - 9 930 mg/kg bw

Applicant's summary and conclusion