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Diss Factsheets

Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
20 Apr-3 May 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: EU test method L383 A/54-62 (EEC A.6)
Qualifier:
according to guideline
Guideline:
other: OECD 105
Principles of method if other than guideline:
Similar experimental conditions applied as required for water solubility determinantion according to guidelines listed above.
GLP compliance:
no
Medium:
n-octanol
Solubility:
43 g/L
Temp.:
20 °C
Remarks on result:
other: pH value as mentioned in the guidelines cannot be indicated because it is defined for aqueous and not octanol solutions.
Test substance stable:
yes

Study results:

Incubation time, h

Weighted sample, g

Concentration, g/L

24

4.508

43.08

48

4.497

43.06

72

4.502

42.87

A concentration plateau could be reached over 72 hours at 30 °C with 24 hours subsequent incubation at 20 °C.

Total average concentration over three incubation times was 43.0 g/L, RSD 0.3%.

Description of key information

n-Octanol solubility: 43 g/L at 20 °C

Key value for chemical safety assessment

Additional information

The solubility of the substance in n-octanol was determined applying similar experimental conditions as described for determination of water solubility according to EU Method A.6 and OECD Guideline 105 (flask method).