Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1949
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from handbook or collection of data, important study details and confidence interval given, considered reliable.

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data, list III
Author:
Smyth H.F. ; Carpenter C.P.; Weil C.S.
Year:
1949
Bibliographic source:
The Journal of Industrial Hygiene and Toxicolology, 31(1), 60-62

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: see Principles of method if other than guideline
Principles of method if other than guideline:
Method: other: For details not reported in this publication see previous publications in J. Ind. Hyg. Toxicol. 26, 269-273 (1944) and J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
Test substance: 3,3,5-Trimethylcyclohexanol, no further data no further information about the isomeric ratio

Test animals

Species:
rat
Strain:
Sherman
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
four doses in a geometrical series
No. of animals per sex per dose:
5

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
3 250 mg/kg bw

Any other information on results incl. tables

Confidence interval ("fiducial range"): 2740 - 3860 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Remarks:
Migrated information
Conclusions:
An acute oral toxicity LD50 for male rats of 3250 mg/kg (CI 2740 - 3860 mg/kg bw) was obtained in a published study from 1949. The study is taken as key study for the asssessment.
Executive summary:

The LD50 for acute oral toxicity in male rats is 3250 mg/kg (CI 2740 - 3860 mg/kg bw) as published in the study from Smyth et al. (1949) for the substance 3,3,5-Trimethylcyclohexanol . The study is taken as key study for the asssessment.