Registration Dossier
Registration Dossier
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EC number: 213-268-0 | CAS number: 933-48-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1949
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from publication containing range finding results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 949
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: see Principles of method if other than guideline
- Principles of method if other than guideline:
- Method: other: For details not reported in this publication see previous publication in Am. J. Ophthalmol. 29, 1363-1372 (1946).
- GLP compliance:
- no
Test material
- Reference substance name:
- cis-3,5,5-trimethylcyclohexan-1-ol
- EC Number:
- 213-268-0
- EC Name:
- cis-3,5,5-trimethylcyclohexan-1-ol
- Cas Number:
- 933-48-2
- Molecular formula:
- C9H18O
- IUPAC Name:
- (1R,5R)-3,3,5-trimethylcyclohexan-1-ol
- Details on test material:
- Test substance: other TS: 3,3,5-Trimethylcyclohexanol, no further data; no further information about the isomeric ratio
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- open
- Vehicle:
- other: initially none; acetone for dilution series of corrosive substances
- Amount / concentration applied:
- undiluted total volume applied : 0.01 ml
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- 24 hours after exposure
- Number of animals:
- 5
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 5
- Max. score:
- 10
- Reversibility:
- no data
- Remarks on result:
- other: strong erythema, edema, or slight necrosis
Any other information on results incl. tables
Irritation index: 5 (= strong erythema, edema, or slight necrosis)
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Conclusions:
- In a range finding studies with rabbits the skin irritation was determined at a scaling of 5 out of 10. The study is used as key study.
- Executive summary:
In a range finding studies with rabbits the skin irritation was determined at a scaling of 5 out of 10.
Strong erythema, edema or light necrosis were observed. Based on the results the substance is considered to be irritant to skin. The study is used as key study.
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