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EC number: 213-268-0 | CAS number: 933-48-2
Endpoint summary
Administrative data
Description of key information
Acute toxicity: oral: LD50 = 3250 mg/kg bw (WoE).
Acute toxicity: dermal: LD50 = 2430 mg/kg bw ( WoE).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1949
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from handbook or collection of data, important study details and confidence interval given, considered reliable.
- Qualifier:
- according to guideline
- Guideline:
- other: see Principles of method if other than guideline
- Principles of method if other than guideline:
- Method: other: For details not reported in this publication see previous publications in J. Ind. Hyg. Toxicol. 26, 269-273 (1944) and J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sherman
- Sex:
- male
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- four doses in a geometrical series
- No. of animals per sex per dose:
- 5
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 250 mg/kg bw
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- An acute oral toxicity LD50 for male rats of 3250 mg/kg (CI 2740 - 3860 mg/kg bw) was obtained in a published study from 1949. The study is taken as key study for the asssessment.
- Executive summary:
The LD50 for acute oral toxicity in male rats is 3250 mg/kg (CI 2740 - 3860 mg/kg bw) as published in the study from Smyth et al. (1949) for the substance 3,3,5-Trimethylcyclohexanol . The study is taken as key study for the asssessment.
Reference
Confidence interval ("fiducial range"): 2740 - 3860 mg/kg bw
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 250 mg/kg bw
- Quality of whole database:
- Reliable with restrictions (Klimisch Code 2)
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1949
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from handbook or collection of data, important study details and confidence interval given, considered reliable.
- Qualifier:
- according to guideline
- Guideline:
- other: see Principles of method if other than guideline
- Principles of method if other than guideline:
- Method: other: For details not reported in this publication see previous publications in J. Ind. Hyg. Toxicol. 26, 269-273 (1944) and J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rabbit
- Type of coverage:
- occlusive
- Vehicle:
- other: none (i.e. undiluted test substance)
- Doses:
- four dosages in a geometrical series
- No. of animals per sex per dose:
- 5
- Dose descriptor:
- LD50
- Effect level:
- 2 430 mg/kg bw
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- A dermal study with rabbits applying the test substance in four doses yields a LD50 reported as 2.8 ml/kg bw. The study was taken as key study for 3,3,5-trimethylcyclohexanole.
- Executive summary:
A LD50 was reported for acute dermal toxicity as 2.8 ml/kg bw for the test substance in rabbits. The study was taken as key study for 3,3,5-trimethylcyclohexanol.
Reference
LD50 reported as 2.8 ml/kg bw
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 430 mg/kg bw
- Quality of whole database:
- Reliable with restrictions (Klimisch Code 2)
Additional information
An acute oral toxicity LD50 for male rats of 3250 mg/kg (CI 2740 - 3860 mg/kg bw) was obtained in a published study from 1949. The study is taken as key study for the asssessment.
A dermal study with rabbits applying the test substance in four doses yields a LD50 reported as 2.8 ml/kg bw. The study was taken as key study for 3,3,5-trimethylcyclohexanole.
Justification for selection of acute toxicity – oral endpoint
Data from handbook or collection of data, important study details and confidence interval given, considered reliable.
Justification for selection of acute toxicity – dermal endpoint
Data from handbook or collection of data, important study details and confidence interval given, considered reliable.
Justification for classification or non-classification
Based on the available acute toxicity results in rodents the substance does not need to be classified for acute toxicity under EC 1272/2008 or the dangerous substance directive 548/67/EEC.
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