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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1949
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from handbook or collection of data, important study details and confidence interval given, considered reliable.

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data, list III
Author:
Smyth H.F. ; Carpenter C.P.; Weil C.S.
Year:
1949
Bibliographic source:
The Journal of Industrial Hygiene and Toxicolology, 31(1), 60-62

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: see Principles of method if other than guideline
Principles of method if other than guideline:
Method: other: For details not reported in this publication see previous publications in J. Ind. Hyg. Toxicol. 26, 269-273 (1944) and J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
GLP compliance:
no
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: 3,3,5-Trimethylcyclohexanol, no further data; no further information about the isomeric ratio

Test animals

Species:
rabbit

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: none (i.e. undiluted test substance)
Doses:
four dosages in a geometrical series
No. of animals per sex per dose:
5

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
2 430 mg/kg bw

Any other information on results incl. tables

LD50 reported as 2.8 ml/kg bw

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Remarks:
Migrated information
Conclusions:
A dermal study with rabbits applying the test substance in four doses yields a LD50 reported as 2.8 ml/kg bw. The study was taken as key study for 3,3,5-trimethylcyclohexanole.
Executive summary:

A LD50 was reported for acute dermal toxicity as 2.8 ml/kg bw for the test substance in rabbits. The study was taken as key study for 3,3,5-trimethylcyclohexanol.