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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1949
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data, list III.
Author:
Smyth HF Jr, Carpenter CP and Weil CS . J. Ind. Hyg. Toxicol. 31, 60-62.
Year:
1949
Bibliographic source:
J. Ind. Hyg. Toxicol. 31, 60-62.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: see Principles of method if other than guideline
Deviations:
not applicable
Principles of method if other than guideline:
Method: other: For details not reported in this publication see previous publications in J. Ind. Hyg. Toxicol. 26, 269-273 (1944) and J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
cis-3,5,5-trimethylcyclohexan-1-ol
EC Number:
213-268-0
EC Name:
cis-3,5,5-trimethylcyclohexan-1-ol
Cas Number:
933-48-2
Molecular formula:
C9H18O
IUPAC Name:
(1R,5R)-3,3,5-trimethylcyclohexan-1-ol
Details on test material:
Test substance: other TS: 3,3,5-Trimethylcyclohexanol, no further data, no further information about the isomeric ratio

Test animals / tissue source

Species:
rabbit
Strain:
other: Albino (not specified)

Test system

Amount / concentration applied:
undiluted
Duration of treatment / exposure:
24 hour(s)
Number of animals or in vitro replicates:
5
Details on study design:
Comment: not rinsed

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Time point:
other: 24 h
Score:
9
Max. score:
20

Any other information on results incl. tables

Grade 9

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information
Conclusions:
The eye irritation was rated 9 out of 20 points in a study with albino rabbits. A score of >5 was indicated as severe injury
Executive summary:

A eye irritating study was conducted with albino rabbits. The eye irritation was rated 9 out of 20 points. A score of >5 was indicated as severe injury. Hence under the conditions of this study the substance is considered to be irritating to eyes.