Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1949
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data, list III.
Author:
Smyth HF Jr, Carpenter CP and Weil CS . J. Ind. Hyg. Toxicol. 31, 60-62.
Year:
1949
Bibliographic source:
J. Ind. Hyg. Toxicol. 31, 60-62.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: see Principles of method if other than guideline
Deviations:
not applicable
Principles of method if other than guideline:
Method: other: For details not reported in this publication see previous publications in J. Ind. Hyg. Toxicol. 26, 269-273 (1944) and J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: other TS: 3,3,5-Trimethylcyclohexanol, no further data, no further information about the isomeric ratio

Test animals / tissue source

Species:
rabbit
Strain:
other: Albino (not specified)

Test system

Amount / concentration applied:
undiluted
Duration of treatment / exposure:
24 hour(s)
Number of animals or in vitro replicates:
5
Details on study design:
Comment: not rinsed

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Time point:
other: 24 h
Score:
9
Max. score:
20

Any other information on results incl. tables

Grade 9

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information
Conclusions:
The eye irritation was rated 9 out of 20 points in a study with albino rabbits. A score of >5 was indicated as severe injury
Executive summary:

A eye irritating study was conducted with albino rabbits. The eye irritation was rated 9 out of 20 points. A score of >5 was indicated as severe injury. Hence under the conditions of this study the substance is considered to be irritating to eyes.