Registration Dossier
Registration Dossier
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EC number: 954-921-6 | CAS number: -
Stability in organic solvents and identity of relevant degradation products
Administrative data
Link to relevant study record(s)
- Endpoint:
- stability in organic solvents and identity of relevant degradation products
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC method MT 157.3
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test substance stable:
- yes
- Conclusions:
- The substance was soluble and stable in the set of organic solvents tested.
- Executive summary:
The solubility of the substance was determined under GLP in seven organic solvents to a procedure similar to that described in CIPAC method MT 157.3 (water solubility, flask method). Appropriately weighed amounts of test substance were dissolved in a defined volume of 50 mL of the respective organic solvent at a temperature of 25 °C. One day and two days after the preparation of the saturated solutions, a representative aliquot was removed from each of the flasks and transferred to a stainless steel centrifuge tube. These tubes were then centrifuged for forty minutes at 48000 G in a centrifuge, thermostated at 25 °C. After centrifugation, each centrifuge tube contained a clear liquid - saturated solution - with undissolved, excess test item still present. An aliquot was then removed from each clear, saturated solution and analysed by an appropriate reversed phase HPLC method.
Reference
The solubilities determined at 25 °C in different solvents were as follows:
Acetone: 270 g/L
Dichloromethane: 400 g/L
Ethyl acetate: 190 g/L
Hexane: 39 mg/L
Methanol: 75 g/L
Octanol: 17 g/L
Toluene: 33 g/L
Description of key information
The substance is soluble and stable in a set of organic solvents. Solubility was tested under GLP to a procedure that is similar to that described in CIPAC method MT 157.3 (water solubility, flask method). Clear, saturated solutions of the test substance in each solvent were prepared at 25 °C, and the concentration of the substance was determined after one and two days of equilibration.
The following solubilities were determined:
Acetone: 270 g/L
Dichlormethane: 400 g/L
Ethyl acetate: 190 g/L
Hexane: 39 mg/L
Methanol: 75 g/L
Octanol: 17 g/L
Toluene: 33 g/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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