Isocycloseram

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

5 Nov 2017 to 15 Nov 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

July 1995

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

May 2008

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Key result

Melting / freezing pt.:

135.3 °C

Atm. press.:

>= 100.1 - <= 100.2 kPa

Decomposition:

no

RESULTS

The mean melting temperature of the test item was 135.3 °C (408.4 K). A standard deviation of 0.54 °C was obtained from the four replicate determinations performed, resulting in a percentage relative standard deviation of 0.40 %. Atmospheric pressure: 100.1 to 100.2 kPa. Essentially identical thermograms were observed in both air and a nitrogen atmosphere. A change in appearance for the remaining residue, that of an amber colored solid, as opposed to returning to a white colored solid, was observed during all determinations.

Table 1: Thermographic Data – Determination 1

Thermal Event	Interpretation	Temperature
		ºC	K
Extrapolated endotherm onset temperature.	Melting temperature.	135.63	408.8

Table 2: Thermographic Data – Determination 2

Thermal Event	Interpretation	Temperature
		ºC	K
Extrapolated endotherm onset temperature.	Melting temperature.	135.65	408.8

 

Table 3: Thermographic Data – Determination 3

Thermal Event	Interpretation	Temperature
		ºC	K
Extrapolated endotherm onset temperature.	Melting temperature.	135.24	408.4

 

Table 4: Thermographic Data – Determination 4

Thermal Event	Interpretation	Temperature
		ºC	K
Extrapolated endotherm onset temperature.	Melting temperature.	134.50	407.7

Conclusions:

The melting point of the test substance was determined to be 135.3 °C (408.4 K) at 100.1 to 100.2 kPa.

Executive summary:

The study was performed to determine the melting temperature of the test item according to OECD TG 102 and EC MEthod A.3 and in compliance with GLP. Using the differential scanning calorimetry method, the mean melting temperature of the test substance was determined to be 135.3 °C (408.4 K) at 100.1 to100.2 kPa ffrom the four determinations performed. The relative standard deviation for the performed measurements was 0.40 %.

Description of key information

Melting point = 135.3 °C (408.4 K), OECD 102, differential scanning calorimetry, O'Connor 2017

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

135.3 °C