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EC number: 701-326-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
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- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
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- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2009-01-28 to 2009-05-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. No deviation affected the good quality of the study. The substance is considered to be adequately characterised with its purity. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Inspected on 05th to 06th and 26th to 30th November 2007 / Decision 30 April 2008 / Signed on 12th November 2008
- Type of method:
- column elution method
- Key result
- Water solubility:
- 1.88 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- 95 h
- Temp.:
- 20 °C
- pH:
- 6.5
- Executive summary:
The water solubility of the test substance was measured under GLP according OECD 105 / EU A6 guideline, column elution method.
After calibration with six standard solutions, two experiments were conducted, with different flow rate, for 95h total elution time. Constant concentrations, measured by GC-FID, were observed, i.e. saturation achieved, and both results did not significantly differ, therefore the mean value was retained. pH was stable for all samples.
The water solubility of the test substance is 1.88 mg/L at 20°C (pH=6.5).
Reference
During the main test, six samples have been analyzed in the first run (0.52 mL/min) and six samples during the second run (0.26 mL/min), each with a sampling interval of one hour. Total elution time was 95 hours. The sample measurement was performed by GC. The water solubility at 20 °C was determined to be 1.88 mg/L. The measured results differ by less than 30%. Therefore, the study is considered to be valid.
Experiment No. | Flow rate [mL/h] | Sample No. | Concentration analyzed [mg/L] | Water solubility [mg/L] | pH | |
1 | 31 | 1 | 1.793 | 1.849 SD +/- 0.08 SDrel = 4.43% |
1.88 | 6.50 |
2 | 1.857 | 6.49 | ||||
3 | 1.837 | 6.51 | ||||
4 | 1.731 | 6.51 | ||||
5 | 1.919 | 6.52 | ||||
6 | 1.956 | 6.50 | ||||
2 | 16 | 7 | 1.942 | 1.906 SD +/- 0.07 SDrel = 3.93% |
6.51 | |
8 | 1.881 | 6.49 | ||||
9 | 2.012 | 6.52 | ||||
10 | 1.791 | 6.50 | ||||
11 | 1.875 | 6.51 | ||||
12 | 1.933 | 6.51 |
SD = Standard Deviation
SD rel. = Relative Standard Deviation
The r² fit of the calibration curve (n=6) was 1.0000. This reflects the linearity of the GC-system within the calibration range of 0.3235 mg/L to 16.175 mg/L of the test item.
Description of key information
Slightly soluble. pH of saturated solution: 6.5.
Key value for chemical safety assessment
- Water solubility:
- 1.88 mg/L
- at the temperature of:
- 20 °C
Additional information
A fully reliable study, conducted according to a recognized OECD/EU method and under GLP, is available. It is considered as a key study, and the result is retained as key data for purpose of CSA.
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