Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 605-140-1 | CAS number: 158237-07-1
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Description of key information
Based on the acute effect concentrations, aquatic invertebrates cannot be identified as the most sensitive organism and it is not expected that a chronic study will result in even lower effect concentrations compared to algae.
Key value for chemical safety assessment
Additional information
According to Regulation (EC) No 1907/2006, Annex IX, Column 2, long-term toxicity testing shall be proposed by the registrant if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on aquatic organisms.
In acute aquatic toxicity tests algae (ErC50 (72 h) = 6.04 µg/L, NOErC (72 h) = 0.49 µg/L, initial measured) demonstrated being by far the most sensitive organisms, resulting in T (toxic) for PBT assessment. The difference between sensitivity demonstrated in aquatic invertebrates (EC50 (48 h) = 100 µg/L, nominal) and algae is around factor 16. According to the Guidance on information requirements and chemical safety assessment Chapter R.7b: Endpoint specific guidance, R.7.8.5.3 (ECHA, 2017), there are no further requirements for invertebrate testing if there is compelling evidence to suggest that the invertebrate value is likely to be at least a factor of about 10 less sensitive than algae or fish. Therefore, it is neither to be expected that a chronic aquatic invertebrate study will yield even lower effect values nor will it contribute to a more stricter toxicity (T) assessment compared to algae. The substance is classified as Aquatic Chronic 1 (H410) and Aquatic Acute 1 (H400) according to the consolidated version of Regulation (EC) No 1272/2008 and further amendments (ATPs) which is the highest aquatic toxicity classification.
In addition, the environmental exposure assessment for the test substance according to Annex XI, Section 3 of Regulation (EC) No 1907/2006 indicates no risk for the aquatic compartment (all RCR < 1; please refer to Chapter 9 and 10 of the Chemical Safety Report for detailed information). Thus, a long-term test with aquatic invertebrates is not deemed necessary. Since, the substance is a herbicide which implicates plants to be the most sensitive organism group with the highest expected toxicity. Thus, no higher toxicity is expected for fish than for algae and no chronic test is proposed for fish.
Hence, based on the acute effect concentrations, aquatic invertebrates cannot be identified as the most sensitive organism and it is not expected that a chronic study will result in even lower effect concentrations compared to algae. Thus, no further long-term test with aquatic invertebrates was proposed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
