4-(2-chlorophenyl)-N-cyclohexyl-N-ethyl-5-oxo-4,5-dihydro-1H-tetrazole-1-carboxamide

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Oct 12 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)

Qualifier:

according to guideline

Guideline:

other: Guidance on information requirements and chemical safety assessment, chapter r.7a: Endpoint specific guidance, version 5.0, Oct 2016, ECHA

GLP compliance:

yes (incl. QA statement)

Remarks:

Hess. Ministerium für Umwelt, Klimaschutz, Landwirtschaft und Verbraucherschutz, Mainzer Straße 80, D65189 Wiesbaden

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Specific details on test material used for the study:

The sample was tested as received. No further preliminary treatment such as drying or milling was performed.

Percentile:

D10

Mean:

20.9 µm

Remarks on result:

other: a standard deviation of particle size is not given

Remarks:

refers to 35.4 % (w/w) of th test item after sieving with a mesh size of 1000 µm

Percentile:

D50

Mean:

49 µm

Remarks on result:

other: a standard deviation of particle size is not given

Remarks:

refers to 35.4 % (w/w) of th test item after sieving with a mesh size of 1000 µm

Percentile:

D90

Mean:

293.9 µm

Remarks on result:

other: a standard deviation of particle size is not given

Remarks:

refers to 35.4 % (w/w) of th test item after sieving with a mesh size of 1000 µm

No.:

#1

Size:

< 1 000 µm

Distribution:

35.4 %

Individual results

The test item consisted of particles which were partly transparent. The formation of agglomerates with various shapes was observed. For this reason the test item was sieved with a mesh size of 1000 µm before measurement. 35.4 % (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction.

The test item was tested as a liquid dispersion in demineralized water (with 1 % detergent). Before the measurement two spatula points of the test item were mixed with approx. 2 ml demineralized water (with 1 % detergent) and homogenised. This homogenised dispersion was fed to the sample unit, which was filled with demineralized water (with 1 % detergent). Subsequently the diluted dispersion was pumped back into the small volume sample dispersion unit.

After adjusting the laser, measuring the background (demineralized water with 1% detergent) and adjusting the correct particle concentration (obscuration) the measurement was started. The control software automatically performed three measurements. The average of these three measurements was given as result. Two test series of three measurements each were performed. The measurement time was 12 s.

For each test series fractions (left axis of the ordinate) and the siftings (right axis of the ordinate) are presented in volume % as a function of the particle size.

The median particle size L₅₀(D (v, 0.5): 50% of particle volume or particle mass with lower particle diameter) deduced from these distributions are:

1^sttest series: L₅₀= 47.34 µm

2^ndtest series: L₅₀= 50.75 µm

The average of the median particle size L₅₀ is 49.0 µm.

The particle size L₁₀(D (v, 0.1): 10% of particle volume or particle mass with lower particle diameter) deduced from these distributions are:

1^sttest series: L₁₀= 20.62 µm

2^ndtest series: L₁₀= 21.10 µm

The average of the median particle size L₁₀ is 20.9 µm.

The particle size L₉₀(D (v, 0.9): 90% of particle volume or particle mass with lower particle diameter) deduced from these distributions are:

1^sttest series: L₉₀= 293.27 µm

2^ndtest series: L₉₀= 294.55 µm

The average of the median particle size L₉₀ is 293.9 µm.

The measurements showed maxima at approximately 40 µm and 200 µm. A shoulder was observed at approximately 5 µm.

Final results

The test item consisted of particles which were partly transparent. The test item was sieved with a mesh size of 1000 µm before measurement. 35.4 % (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction.

The median particle size L₅₀ of the test item deduced from the particle size distribution is 49.0 µm.

The particle size L₁₀ of the test item deduced from the particle size distribution is 20.9 µm.

The particle size L₉₀ of the test item deduced from the particle size distribution is 293.9 µm.

Description of key information

The test item consisted of particles which were partly transparent. The test item was sieved with a mesh size of 1000 μm before measurement. 35.4 % (w/w) of the test item passed the sieve and only this

fraction was measured with laser diffraction.

median particle size L₅₀= 49.0 µm

particle size L₁₀= 20.9 µm

particle size L₉₀= 293.9 µm

(CIPAC MT 187, laser diffraction)