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Partition coefficient

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Endpoint:
partition coefficient
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance has a high surface activity
Reason / purpose for cross-reference:
data waiving: supporting information
Reason / purpose for cross-reference:
data waiving: supporting information
Endpoint:
partition coefficient
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Verschueren (1983) reports that octanol-water partition coefficients can be estimated for a wide range of substances as follows:
 
Log Kow= 4.5 – 0.75 Log S                                             
Where S = water solubility in mg/L
Guideline:
other:
Version / remarks:
Verschueren (1983) calculation method
Principles of method if other than guideline:
Verschueren, K., 1983. Relationship between aqueous solubility and octanol/water partition coefficient. In: K. Verschueren, ed. Handbook of Environmental Data on Organic Chemicals. New York: Van Nostrand Reinhold Company Inc., pp. 24-27.
GLP compliance:
no
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
25 °C
pH:
ca. 7
Remarks on result:
other: calculated value
Conclusions:
It is not possible to measure the Log Kow as the substance is surface active. The Log Kow has been calculated based on the water solubility of >40% in water as Log Kow <0.30.

Description of key information

The study does not need to be conducted because the substance has a high surface activity. The calculated value based on the water solubility of > 40% is Log Kow < 0.30.

Key value for chemical safety assessment

Log Kow (Log Pow):
0.3

Additional information