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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 2018-01-29 to 2018-03-30
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Batch No.: 20170707
Purity: 99.13%
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
0.94
Temp.:
20 °C
Remarks on result:
other: pH unknown

n-OCTANOL/WATER PARTITION COEFFICIENT DETERMINATION

 

Volume

Ratio

(noctanol: water)

Vessel #   Phase Dil. Factor   Pow  Log Pow

Avg. Pow ± SD

 
1:1            1    Octanol   9
8.868     
    0.95

               0.94± 0.01

Water 
2 Octanol  8.828    0.95  
Water  1
2:1      1  Octanol  9 8.830        0.95  
Water 
 2 Octanol   9 8.726 0.94    
 Water  1
1:2            1  Octanol  9  8.565    0.93  
 Water  1
2      Octanol  9   8.702   0.94    
 Water  1
Conclusions:
The LogPow of test item is determined as 0.94 at 20°C.
Executive summary:

The partition coefficient (n-octanol/water) of the test substance was determined by the shake flask method followed with capillary HPLC determination as outlined in OPPTS 830.7550, and OECD TG 107.

The LogPow of test item is determined as 0.94 at 20°C.

Description of key information

The LogPow of test item is determined as 0.94 at 20°C.

Key value for chemical safety assessment

Log Kow (Log Pow):
0.94
at the temperature of:
20 °C

Additional information

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