Registration Dossier
Registration Dossier
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EC number: 479-410-0 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Validated industry computer model that is appropriate for use with this petroleum substance
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The aquatic toxicity was estimated by a QSAR, the PETROTOX computer model. This model combines Target Lipid Model used to calculate acute and long-term toxicity of non-polar narcotic chemicals with a partitioning model used to calculate the aqueous concentration of hydrocarbon components.PETROTOX calculates toxicity based on the combined total of membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and selected organism and the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance.
- GLP compliance:
- no
- Remarks:
- The data were calculated by a computer model."
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- other: QSAR modelled data
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
Results and discussion
Effect concentrations
- Duration:
- 21 d
- Dose descriptor:
- other: NOEL
- Effect conc.:
- 0.167 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- immobilisation
Applicant's summary and conclusion
- Executive summary:
The aquatic toxicity was estimated by a QSAR, the PETROTOX computer model. This model combines Target Lipid Model used to calculate acute and long-term toxicity of non-polar narcotic chemicals with a partitioning model used to calculate the aqueous concentration of hydrocarbon components.PETROTOX calculates toxicity based on the combined total of membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and selected organism and the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance.
The estimated freshwater invertebrate NOEL (No Observed Effect Level) value is 0.167 mg/l based on immobility and numbers of live young produced per adult by Day 21.
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