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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
12 March to 29 June 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
not specified
Type of method:
column elution method
Key result
Water solubility:
< 0.846 µg/L
Temp.:
20 °C
pH:
6.3

Study results

 

Quantitative determination of the analyte

 

The results of the two experiments are summarized in the following table:

 

Flow rate

[mL/h]

Fraction No.

Volume of combined fractions

[mL]

Test Item

[µg/L]

12.5

1 (1-2)

20

< 0.846

2 (3-4)

20

< 0.846

3 (5-6)

20

< 0.846

4 (7-8)

20

< 0.846

5 (9-10)

20

< 0.846

6 (11-12)

20

< 0.846

7 (13-14)

20

< 0.846

8 (15-16)

20

< 0.846

6.25

1 (1-2)

20

< 0.846

2 (3-4)

20

2.33

3 (5-6)

20

< 0.846

4 (7-8)

20

< 0.846

5 (9-10)

20

< 0.846

6(11-12)

20

< 0.846

7(13-14)

20

< 0.846

8 (15-16)

20

< 0.846

 

As described in OECD 105 a concentration plateau is reached, if at least 5 consecutive fractions do not differ by more than 30%. This is achieved for all evaluations, except the evaluation of the second run at a flow rate of 6.25 mL/h. Determination of the water solubility at both flow rates yielded values below the limit of quantification (LOQ).

The water solubility was determined at 20 °C. The pH value of the collected aqueous fractions was 6.3.

Description of key information

Water solubility < 0.846 µg/L at 20 °C, pH 6.3 (OECD Guideline 105, column elution method)

Key value for chemical safety assessment

Additional information

Determination of the water solubility yielded values below the limit of quantification (LOQ = 0.846 µg/L, as determined by calibration)

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