Hexadecyl palmitate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12 March to 29 June 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

not specified

Type of method:

column elution method

Key result

Water solubility:

< 0.846 µg/L

Temp.:

20 °C

pH:

6.3

Study results

 

Quantitative determination of the analyte

 

The results of the two experiments are summarized in the following table:

 

Flow rate [mL/h]	Fraction No.	Volume of combined fractions [mL]	Test Item [µg/L]
12.5	1 (1-2)	20	< 0.846
	2 (3-4)	20	< 0.846
	3 (5-6)	20	< 0.846
	4 (7-8)	20	< 0.846
	5 (9-10)	20	< 0.846
	6 (11-12)	20	< 0.846
	7 (13-14)	20	< 0.846
	8 (15-16)	20	< 0.846
6.25	1 (1-2)	20	< 0.846
	2 (3-4)	20	2.33
	3 (5-6)	20	< 0.846
	4 (7-8)	20	< 0.846
	5 (9-10)	20	< 0.846
	6(11-12)	20	< 0.846
	7(13-14)	20	< 0.846
	8 (15-16)	20	< 0.846

 

As described in OECD 105 a concentration plateau is reached, if at least 5 consecutive fractions do not differ by more than 30%. This is achieved for all evaluations, except the evaluation of the second run at a flow rate of 6.25 mL/h. Determination of the water solubility at both flow rates yielded values below the limit of quantification (LOQ).

The water solubility was determined at 20 °C. The pH value of the collected aqueous fractions was 6.3.

Description of key information

Water solubility < 0.846 µg/L at 20 °C, pH 6.3 (OECD Guideline 105, column elution method)

Additional information

Determination of the water solubility yielded values below the limit of quantification (LOQ = 0.846 µg/L, as determined by calibration)