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EC number: 200-677-4 | CAS number: 68-11-1
- Life Cycle description
- Uses advised against
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- 2 animals per dose levels
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Mercaptoacetic acid
- EC Number:
- 200-677-4
- EC Name:
- Mercaptoacetic acid
- Cas Number:
- 68-11-1
- Molecular formula:
- C2H4O2S
- IUPAC Name:
- 2-sulfanylacetic acid
- Details on test material:
- Test compound: Thioglycolic acid
CAS no.: 68-11-1
Source: Evans Chemetics Inc.
Batch: ba-93B-109
Purity: 98.2%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- Twenty-four hours prior to applying the test materials, the entire trunk of the rabbits to be used were clipped free of hair with electric clippers. The test materials were applied under a heavy gauge plastic cuff. The cuff was held in place with rubber bands and covered with a cloth bandage which was taped securely to the marginal hair. Thioglycolic acid was applied as a solution in water.
- Duration of exposure:
- 24 hours
- Doses:
- 252, 500, 1000 or 2000 mg/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- After application of the test material, the animals were placed in individual holding cages with free access to food and water. At the end of the 24-hour exposure period, the cuffs were removed and the skin was washed with soap and water, rinsed thoroughly, and dried with a towel. The animals were observed for signs of toxicity during the exposure and periodically for two weeks or more thereafter. Body weights were recorded before and after the exposure period and at intervals up to two-weeks post-application or until the pre-exposure body weights were surpassed.
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 848 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 505 - 1 430
- Mortality:
- Dose # dead/# treated Time of Death
250 0/4 ---
500 1/4 Day 1
1000 2/4 Day 1, 1
2000 4/4 Day 1, 1, 1, 1 - Clinical signs:
- other: Topical effects noted after removal of the cuff were slight to moderate erythema, slight to moderate oedema and slight to moderate necrosis in all cases (no other clinical signs were reported).
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Executive summary:
In a non-guideline acute dermal toxicity study, 4 groups of 2 New Zealand whiterabbits per sex were dosed with 250, 500, 1000 or 2000 mg/kg bw thioglycolic acid (purity 98.2%). Animals were observed for 14 days following the exposure for mortality and clinical signs. Mortality was 0/4, 1/4, 2/4 and 4/4 on day one. No other effects than a skin irritation at the site of application was reported. The LD50was 848 mg/kg bw.
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