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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Some aspects of the absorption, distribution and excretion of sodium thioglycolate
Author:
Freeman MV, Draize JH and Smith PK
Year:
1956
Bibliographic source:
J Pharmacol exp Ther, 118, 304-308

Materials and methods

Objective of study:
excretion
Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test compound: sodium thioglycolate labeled with S35
CAS no.: 367-51-1
Source: Tracerlab, Inc
Batch: no data
Radiochemical activity: 0.66 mc per mM
Radiochemical purity: no data
Radiolabelling:
yes

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Control animals:
yes, concurrent no treatment
Details on study design:
In studies using 6 rats, 24-hour urine collections were made following  intraperitoneal administration of 2.5% aqueous labelled sodium  thioglycolate (12.5-75 mg/kg body weight)

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:
Of the total sulphur administered, significant levels were excreted as  inorganic sulphate (23-72%); the total labelled sulphur excreted during  the first 24 hours was 59-96% of the dose. Two of the rats excreted 9% or  11% on the second day and 2% or 6% on the third day respectively. No  hydrogen sulphide was detected in exhaled air during any of three 10-hour  tests on 1 rat (weight and strain not stated) treated intraperitoneally  with 150 mg sodium thioglycolate/kg bodyweight.

Metabolite characterisation studies

Metabolites identified:
no

Applicant's summary and conclusion

Executive summary:

The urinary excretion of sodium thioglycolate was also evaluated in rats (weight and strain not stated) injected i.p. with 12.5 to 75.0 mg/kg of a 2.5% solution of sodium35S-thioglycolate. Urine was collected over a period of 24 h. Quantities of inorganic sulphate excreted, expressed as % of administered radioactivity, ranged from 23 to 72%. The total labelled sulphur excreted during the first 24 hours was 59-96% of the dose. Two of the rats excreted 9% or 11% on the second day and 2% or 6% on the third day respectively.