Registration Dossier
Registration Dossier
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EC number: 200-677-4 | CAS number: 68-11-1
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Some aspects of the absorption, distribution and excretion of sodium thioglycolate
- Author:
- Freeman MV, Draize JH and Smith PK
- Year:
- 1 956
- Bibliographic source:
- J Pharmacol exp Ther, 118, 304-308
Materials and methods
- Objective of study:
- excretion
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium mercaptoacetate
- EC Number:
- 206-696-4
- EC Name:
- Sodium mercaptoacetate
- Cas Number:
- 367-51-1
- Molecular formula:
- C2H4O2S.Na
- IUPAC Name:
- sodium sulfanylacetate
- Details on test material:
- Test compound: sodium thioglycolate labeled with S35
CAS no.: 367-51-1
Source: Tracerlab, Inc
Batch: no data
Radiochemical activity: 0.66 mc per mM
Radiochemical purity: no data
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- In studies using 6 rats, 24-hour urine collections were made following intraperitoneal administration of 2.5% aqueous labelled sodium thioglycolate (12.5-75 mg/kg body weight)
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- Of the total sulphur administered, significant levels were excreted as inorganic sulphate (23-72%); the total labelled sulphur excreted during the first 24 hours was 59-96% of the dose. Two of the rats excreted 9% or 11% on the second day and 2% or 6% on the third day respectively. No hydrogen sulphide was detected in exhaled air during any of three 10-hour tests on 1 rat (weight and strain not stated) treated intraperitoneally with 150 mg sodium thioglycolate/kg bodyweight.
Metabolite characterisation studies
- Metabolites identified:
- no
Applicant's summary and conclusion
- Executive summary:
The urinary excretion of sodium thioglycolate was also evaluated in rats (weight and strain not stated) injected i.p. with 12.5 to 75.0 mg/kg of a 2.5% solution of sodium35S-thioglycolate. Urine was collected over a period of 24 h. Quantities of inorganic sulphate excreted, expressed as % of administered radioactivity, ranged from 23 to 72%. The total labelled sulphur excreted during the first 24 hours was 59-96% of the dose. Two of the rats excreted 9% or 11% on the second day and 2% or 6% on the third day respectively.
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