Registration Dossier
Registration Dossier
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EC number: 200-677-4 | CAS number: 68-11-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of various compounds on the reaction of tris-(2-chloroethyl)amine with ribonucleic acid in vitro and on its toxicity in mice
- Author:
- Szinicz L, Albrecht GJ and Weger N
- Year:
- 1 981
- Bibliographic source:
- Arzneim -Forsch, 31 (11), 1713-1717
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- other: no data
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Mercaptoacetic acid
- EC Number:
- 200-677-4
- EC Name:
- Mercaptoacetic acid
- Cas Number:
- 68-11-1
- Molecular formula:
- C2H4O2S
- IUPAC Name:
- 2-sulfanylacetic acid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Weight: 20-25g
Diet: standard ad libitum
Water: ad libitum
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- physiological saline
- Doses:
- no data
- Statistics:
- LD90, LD50, LD5 calculated according to the Litchfield and Wilcoxon
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 138 mg/kg bw
- 95% CL:
- 133 - 143
- Sex:
- male
- Dose descriptor:
- other: LD5
- Effect level:
- 115 mg/kg bw
- 95% CL:
- 96 - 138
Applicant's summary and conclusion
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