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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment.

Data source

Reference
Reference Type:
publication
Title:
Effect of various compounds on the reaction of tris-(2-chloroethyl)amine with ribonucleic acid in vitro and on its toxicity in mice
Author:
Szinicz L, Albrecht GJ and Weger N
Year:
1981
Bibliographic source:
Arzneim -Forsch, 31 (11), 1713-1717

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
other: no data
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
SMILES: C(=O)(O)CS
Molecular Formula: C2 H4 O2 S1
Molecular weight (g/mole): 92.11

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
Weight: 20-25g
Diet: standard ad libitum
Water: ad libitum

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
physiological saline
Doses:
no data
Statistics:
LD90, LD50, LD5 calculated according to the Litchfield and Wilcoxon

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
138 mg/kg bw
95% CL:
133 - 143
Sex:
male
Dose descriptor:
other: LD5
Effect level:
115 mg/kg bw
95% CL:
96 - 138

Applicant's summary and conclusion