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EC number: 219-676-5 | CAS number: 2495-39-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline with acceptable restrictions (mostly due to reduced reporting in times before GLP)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium prop-2-enesulphonate
- EC Number:
- 219-676-5
- EC Name:
- Sodium prop-2-enesulphonate
- Cas Number:
- 2495-39-8
- Molecular formula:
- C3H6O3S.Na
- IUPAC Name:
- sodium prop-2-ene-1-sulfonate
- Details on test material:
- - Name of test-item: Golpanol SC 9269 = Golpanol ALS
- Batch identification: 04749356P0
- Purity: 25 % in aqua dest.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner
- Mean weight at study initiation: 180 g (male), 160 g (female)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: dest. water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25 %
- Amount of vehicle (if gavage): 10000 µl/kg
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw - Doses:
- 100, 1000, 10000 µl/kg
- No. of animals per sex per dose:
- 5 for the highest dose
2 females for the other doses - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weighing was prior the beginning of the study for dose calculation, on day 3, 7 and 13. Observation of clinical signs was several times on the day of administration and once daily afterwards with exception of weekends.
- Necropsy of survivors performed: yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 1/10 animals died at the highest dose tested
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 1/10 animals died. at the highest dose tested (ca. 12300 mg/kg bw)
- Mortality:
- 1/10 animals died one day after application of 10000 µl/kg bw. No mortality was observed in the other dose groups.
- Clinical signs:
- other: Sporadic dyspnoea, apathy and diarrhoea the first hours after administration of the test substance at the highest dose level.
- Gross pathology:
- Sporadic pneumotic areals in lungs were noted in the animals examined at termination of the study.
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