Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

The study of Mueller and Neumann (1981) assessed the biodegradability of L-histidine according to the Offhaus method. It was not performed according to GLP nor internationally accepted guidelines.

In this study, the biochemical oxygen demand (BOD) was analysed using a Sapromat BOD measuring unit. BOD5 was determined to be 517 mg O2/g for a substance having a COD value of 1023 mg O2/g. The test shows good biological degradation, i.e. 50 % biodegradation after 5 days.

Based on the observed respiration activity, the degradation should take place undisturbed, even at higher concentrations and especially after certain adaptation.

A second study on the biodegradability of L-histidine is available. In this study dating back to

1969, the ability of activated sludges from 3 municipal waste treatment plants to oxidise amino acids

was investigared. The activated sludge (concentration 2500 mg/L) was exposed to L-histidine at a

concentration of 500 mg/L. The biodegradation was assessed during 24h by measurement of the O2

consumption using Warburg flasks. The average biodegradation (as % of theoretical oxygen demand)

over the 3 activated sludges was 16.5 %.

The test was not performed according to GLP nor internationally accepted guidelines.