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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
QSAR using an accepted calculation method. The assessed substance is within the domain of the QSAR.
Qualifier:
no guideline followed
Principles of method if other than guideline:
QSAR calculation
GLP compliance:
no
Type of method:
other: QSAR
Key result
Temp.:
25 °C
Vapour pressure:
0 mm Hg
Remarks on result:
other: Neely, WB and Blau, GE (1985)
Conclusions:
VP: 5.99E-09 mm Hg.
The vapour pressure was calculated by EpiSuite's MPBPVP model.
Executive summary:

The vapour pressure was calculated by EpiSuite's MPBPVP model and found to be 5.99E-09 mm Hg.

This corresponds to a vapour pressure of 7.99E-07 Pa.

L-histidine is considered to be inside the applicability domain of the EpiSuite MPBPVP model since the following criteria are fulfilled:

- the molecular weight of L-histidine is within the molecular weight range of the training set

- L-histidine has a limited number of functional groups

- all functional groups present in L-histidine are represented in the training set and have a fragment coëfficiënt available.

Description of key information

VP: 5.99E-09 mm Hg. (estimated by QSAR). This corresponds to a vapour pressure of 7.99E-07 Pa.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure was calculated by EpiSuite's MPBPVP model and found to be 5.99E-09 mm Hg.

The suitability of the model was assessed and it was concluded that L-histidine is considered to be inside the applicability domain of the EpiSuite MPBPVP model.