Registration Dossier
Registration Dossier
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EC number: 200-745-3 | CAS number: 71-00-1
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- QSAR using an accepted calculation method. The assessed substance is within the domain of the QSAR.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR calculation
- GLP compliance:
- no
- Type of method:
- other: QSAR
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0 mm Hg
- Remarks on result:
- other: Neely, WB and Blau, GE (1985)
- Conclusions:
- VP: 5.99E-09 mm Hg.
The vapour pressure was calculated by EpiSuite's MPBPVP model. - Executive summary:
The vapour pressure was calculated by EpiSuite's MPBPVP model and found to be 5.99E-09 mm Hg.
This corresponds to a vapour pressure of 7.99E-07 Pa.
L-histidine is considered to be inside the applicability domain of the EpiSuite MPBPVP model since the following criteria are fulfilled:
- the molecular weight of L-histidine is within the molecular weight range of the training set
- L-histidine has a limited number of functional groups
- all functional groups present in L-histidine are represented in the training set and have a fragment coëfficiënt available.
Reference
Description of key information
VP: 5.99E-09 mm Hg. (estimated by QSAR). This corresponds to a vapour pressure of 7.99E-07 Pa.
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 25 °C
Additional information
The vapour pressure was calculated by EpiSuite's MPBPVP model and found to be 5.99E-09 mm Hg.
The suitability of the model was assessed and it was concluded that L-histidine is considered to be inside the applicability domain of the EpiSuite MPBPVP model.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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