Registration Dossier

Administrative data

Endpoint:
eye irritation, other
Type of information:
other: The Merck Index
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
The Merck Index - Encyclopedia of Chemicals
Year:
1989
Bibliographic source:
The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989

Materials and methods

Principles of method if other than guideline:
not specified
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4'-chloroacetophenone
EC Number:
202-800-7
EC Name:
4'-chloroacetophenone
Cas Number:
99-91-2
Molecular formula:
C8H7ClO
IUPAC Name:
1-(4-chlorophenyl)ethan-1-one
Test material form:
not specified

Results and discussion

In vitro

Results
Irritation parameter:
other: HIGHLY IRRITATING TO EYES, MUCOUS MEMBRANES
Remarks:
Entry in Merck Index: HIGHLY IRRITATING TO EYES
Remarks on result:
other: HIGHLY IRRITATING TO EYES, MUCOUS MEMBRANES
Remarks:
Entry in Merck Index: HIGHLY IRRITATING TO EYES

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
Entry in Merck Index: HIGHLY IRRITATING TO EYES, MUCOUS MEMBRANES leads to the classification Eye irrit 2, H319 and STOT SE 3, H335
Executive summary:

Entry in Merck Index: HIGHLY IRRITATING TO EYES, MUCOUS MEMBRANES