Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: data from collection of data

Data source

Reference
Reference Type:
publication
Title:
Zur Pharmakologie einiger 1,3-Dioxolane, 1,3-Oxathiolane und 1,3-Dithiolane
Author:
Bekemeier H., Köster D.
Year:
1976
Bibliographic source:
Pharmazie 31, H. 5 (1976)

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
- Principle of test: LD 50 determined in acute toxicity study using 36 mice with an observation time of 24 h.
- Short description of test conditions: not specified
- Parameters analysed / observed: LD50
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4'-chloroacetophenone
EC Number:
202-800-7
EC Name:
4'-chloroacetophenone
Cas Number:
99-91-2
Molecular formula:
C8H7ClO
IUPAC Name:
4'-chloroacetophenone
Test material form:
not specified

Test animals

Species:
mouse
Strain:
other: Agnes-Bluhm
Sex:
not specified
Details on test animals or test system and environmental conditions:
body weight 18-22 g

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
other: water suspension and Tween 80
Details on oral exposure:
not documented
Doses:
not documented
No. of animals per sex per dose:
36 mice in total, no further information given
Details on study design:
Observation: 24 h post exposure
Statistics:
according to Litchfield J. T. jr. and Wilcoxon F., J. Pharmacol. exp. Therapeut, 96, 97 (1949)

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 207 mg/kg bw
95% CL:
>= 1 150 - <= 1 267

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Executive summary:

Mouse LD50 oral 1207 mg/kg was documented in the study of Bekemeier and Köster 1976. Based on this result 4 -chloroacetophenone needs to be classified in category 4 based on GHS criteria, acute tox. 4, H 302.