Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

There are no reports whatsoever on exposure related observations in humans in the public domain, which clearly specified the target substance as 1-(4-chlorophenyl)ethanone.

Additional information

Please note that numerous studies are available describing the effects of chloroacetophenone, which however refer to the active ingredient CN in tear gas (CAS: 532 -27 -4, IUPAC name: 2 -chloro-1 -phenylethanone). In contrast to 2 -chloro-1 -phenylethanone, which is chlorinated at the side chain, 4´-chloroacetophenone (CAS: 99 -91 -02, IUPAC name: 1-(4-chlorophenyl)ethanone) is chlorinated at the core and therefore clearly less reactive. Thus studies using 2 -chloro-1 -phenylethanone are not considered representative for the toxicity assessment of 1-(4-chlorophenyl)ethanone.