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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Deviations:
no
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Deviations:
no
GLP compliance:
yes
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Batch No. 140147K06B
- Expiration date of the batch: 2018-12-17
- Purity test date: 2015-02-18

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: ambient temperature (20+/-5°C), keep away from light and humidity.
Key result
Percentile:
D50
Mean:
204.6 µm
St. dev.:
1.77
Remarks on result:
other:
Percentile:
D10
Mean:
39.5 µm
St. dev.:
0.71
Remarks on result:
other:
Remarks:
mean of two measurements
Percentile:
D90
Mean:
569.2 µm
St. dev.:
12.37
Remarks on result:
other:
Remarks:
mean of two measurements

Test series 1:

D10: 38.5 µm

D50: 202.1 µm

D90: 551.7 µm

Test series 2:

D10: 39.5 µm

D50: 204.6 µm

D90: 569.2 µm

Conclusions:
The test item L-isoleucine has a median particle size D50 = 204.6 µm, which was determined by laser diffraction measurement.
Executive summary:

The particle size distribution of L-isoleucine was determined by means of laser diffraction measurement in accordance with OECD and ISO guidelines and in line with GLP principles.

The test item was found to have a median particle size (D50) of 204.6 µm.

Description of key information

The particle size distribution of L-isoleucine was determined by means of laser diffraction measurement in accordance with OECD and ISO guidelines and in line with GLP principles. The test item was found to have a median particle size (D50) of 204.6 µm.

Additional information

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